Effect of partially hydrolyzed ginsenoside on in vitro Skin permeation and retention of collagen pentapeptide (palmitoyl-KTTKS)
By: Selvaraj, K
.
Contributor(s): Shin, D. C.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(1), Jan-Feb.Description: 76-83p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Although palmitoyllysine threonine threonine lysine serine is claimed to be a useful bioactive peptide molecule
to arrest skin aging, literature on transdermal permeation and retention of the peptide has rarely been reported.
Aim of this study was to investigate the effect of partially hydrolyzed ginsenoside on transdermal permeation
and retention of palmitoyl lysine threonine threonine lysine serine loaded liquid crystalline nanoparticles.
Palmitoyl lysine threonine threonine lysine serine was loaded onto liquid crystalline nanoparticles using a hot
melting and sonication method. Particle size of the liquid crystalline nanoparticles was reduced to <300 nm
after addition of partially hydrolyzed ginsenoside into the constitution of the liquid crystalline nanoparticles
and the polydispersity index indicated a monodisperse state. Transmission electron microscopy showed
multilayered spherical liquid crystalline nanoparticles with dense core and corona like surface. Franz
diffusion cell study demonstrated that skin permeation of palmitoyl lysine threonine threonine lysine serine
was significantly increased when loaded onto liquid crystalline nanoparticles comprising partially hydrolyzed
ginsenoside (p<0.01), and that this was proportional to the amount of the ginsenoside added. The steady
state flux of palmitoyl lysine threonine threonine lysine serine in liquid crystalline nanoparticles comprising
2.84 % ginsenoside increased 4.60 fold and 2.36 fold compared to that of control (solubilized in propylene
glycol) and liquid crystalline nanoparticles without ginsenoside, respectively. Partially hydrolyzed ginsenoside
may be useful as a novel material to improve skin permeation of peptide molecules suffering from low
transdermal absorption.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022627 |
Although palmitoyllysine threonine threonine lysine serine is claimed to be a useful bioactive peptide molecule
to arrest skin aging, literature on transdermal permeation and retention of the peptide has rarely been reported.
Aim of this study was to investigate the effect of partially hydrolyzed ginsenoside on transdermal permeation
and retention of palmitoyl lysine threonine threonine lysine serine loaded liquid crystalline nanoparticles.
Palmitoyl lysine threonine threonine lysine serine was loaded onto liquid crystalline nanoparticles using a hot
melting and sonication method. Particle size of the liquid crystalline nanoparticles was reduced to <300 nm
after addition of partially hydrolyzed ginsenoside into the constitution of the liquid crystalline nanoparticles
and the polydispersity index indicated a monodisperse state. Transmission electron microscopy showed
multilayered spherical liquid crystalline nanoparticles with dense core and corona like surface. Franz
diffusion cell study demonstrated that skin permeation of palmitoyl lysine threonine threonine lysine serine
was significantly increased when loaded onto liquid crystalline nanoparticles comprising partially hydrolyzed
ginsenoside (p<0.01), and that this was proportional to the amount of the ginsenoside added. The steady
state flux of palmitoyl lysine threonine threonine lysine serine in liquid crystalline nanoparticles comprising
2.84 % ginsenoside increased 4.60 fold and 2.36 fold compared to that of control (solubilized in propylene
glycol) and liquid crystalline nanoparticles without ginsenoside, respectively. Partially hydrolyzed ginsenoside
may be useful as a novel material to improve skin permeation of peptide molecules suffering from low
transdermal absorption.
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