Effects of l-ng-monomethyl-arginine on apoptosis of articular chondrocytes (Record no. 15819)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211229141627.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211229b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15205 |
| Author | Wang, Guodong |
| 245 ## - TITLE STATEMENT | |
| Title | Effects of l-ng-monomethyl-arginine on apoptosis of articular chondrocytes |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 134-139p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | We aimed to investigate the effects of L-NG-monomethyl-arginine on the apoptosis of articular chondrocytes. 30 rabbits were randomly divided into six groups (n=5). The pathological changes were detected by Hematoxylin and Eosin staining. The expression levels of synovialfluid and serum nitric oxide were measured. The apoptosis of chondrocytes was tested using the terminal deoxynucleotidyl transferase dUTP nick end labeling assay. The expression levels of reconstituted B-cell lymphoma-2 and human B-cell lymphoma-2 associated X protein in cartilage tissues were detected by immunohistochemical assay. The Mankin score of the model group was signi ficantly higher than that of the control group (p<0.01). The scores significantly decreased in L-NG-monomethyl-arginine treatment groups (p<0.05). The expression levels of B-cell lymphoma-2 associated X protein, apoptosis rate and index of chondrocytes, and those of synovial fluid and serum nitric oxide were markedly higher in the model group than those in the control group (p<0.01). However, the expression levels of B-cell lymphoma-2 in model and control groups were similar (p>0.05). With increasing L-NG-monomethyl-arginine treatment dose, the expression level of B-cell lymphoma-2 and B-cell lymphoma-2/B-cell lymphoma-2 associated X protein ratio were signi ficantly elevated (p<0.05). L-NG-monomethyl-arginine reduced the expressions of synovial fluid and serum nitric oxide, and raised B-cell lymphoma-2/B-cell lymphoma-2 associated X protein ratio, thereby inhibiting chondrocyte apoptosis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15206 |
| Co-Author | He, Bin |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/effects-of-lngmonomethylarginine-on-apoptosis-of-articular-chondrocytes.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-29 | 2021-2022636 | 2021-12-29 | 2021-12-29 | Articles Abstract Database |