| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20220209101437.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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220209b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15965 |
| Author |
Sirin, Salma Sultana |
| 245 ## - TITLE STATEMENT |
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| Title |
In vitro antileishmanial activities of three medicinal plants: argemonemexicana, murraya koenigii and cinnamomum tamala against miltefosine resistant promastigotes of leishmania donovani parasites |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.13(9) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
M P |
| Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
27-33p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objective: Leishmaniasis is one of the neglected tropical diseases in terms of drug development and discovery. Non-responsiveness and resistance to the drug in Leishmaniaspecies need to develop new antileishmanial potentials; herbal medicines could be the alternative one.Methods: In the present study, semi-purified fractions were prepared from the traditionally used three medicinal plants of India: Argemone mexicana (aerial shoot), Murraya koenigii (stem), and Cinnamomum tamala (bark) by using multiple solvent systems (non-polar to polar, beginning with petroleum ether followed by n-hexane, benzene, and chloroform) and an effort was given to assess the leishmanicidal activities against Leishmania donovani miltefosine resistant HePC-R (Ld/MIL-30) promastigotes in vitroand the IC50 concentrations were estimated.Results: The study revealed that the semi-purified fractions of A. mexicana, M. koenigii, and C.tamala have effective antileishmanial activities and the 50% inhibitory concentrations (IC50) are 50 μg/ml, 98 μg/ml, and 200 μg/ml, respectively. At these (IC50) concentrations, these plant semi-purified fractions were found to interfere in lipid and protein biosynthesis, alter cell morphology, DNA content, mitochondrial membrane potential, generating ROS, and apoptosis in promastigotes. The semi-purified fractions were also found noticeably non-toxic towards host splenocytes.Conclusion: These results could suggest that A. mexicana, M. koenigii, and C.tamala could carry potential novel compounds for the development of new drugs against Leishmaniasis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
2656-0097 |
| Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
| Title |
International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.innovareacademics.in/journals/index.php/ijpps/article/view/42349/25274 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
