Development of interpenetrating microspheres of chitosan and gum arabic for epigallocatechin gallate to enhance colonic delivery (Record no. 16937)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220628110341.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220628b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16869 |
| Author | Patel, N. C. |
| 245 ## - TITLE STATEMENT | |
| Title | Development of interpenetrating microspheres of chitosan and gum arabic for epigallocatechin gallate to enhance colonic delivery |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(4), July-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 765-774p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Epigallocatechin gallate is a potent phytomolecule with wide biological activity and is a class III drug. The therapeutic effect is limited, owing to poor stability and limited membrane permeability across the intestine. The aim of this study was to develop and evaluate colon-targeted microspheres of epigallocatechin gallate, using natural polymers. Water-in-oil emulsion crosslinking technique was used to prepare microspheres of epigallocatechin gallate using interpenetrating network of chitosan and gum acacia and glutaraldehyde was used as a crosslinking agent. Prepared microspheres were filled in capsules coated with Eudragit S100. The prepared microspheres were evaluated in vitro for preformulation studies, encapsulation efficiency, micromeritic properties, dissolution studies and stability studies. Fourier transform infrared spectroscopy and differential scanning calorimetry studies had proved that the drug and polymers are compatible. The good flow property of microspheres show that the microspheres are not aggregated. Scanning electron microscope micrographs of microspheres show a rough and folded surface morphology. The microspheres are spherical and uniform in shape. Formulations show good encapsulation efficiency. Formulation F1 to F6 show sustained release of drug for 10 h. The in vitro drug release of batch F1 to F6 were best explained by Higuchi models due to diffusion mechanism of drug release from polymeric matrix system. The selected formulation batch for a period of 3 mo at 40±2°/75±5 % RH show no significant changes. The current approach was helpful to develop polysaccharide based microspheres of epigallocatechin gallate to enhance colonic drug delivery. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16870 |
| Co-Author | Patel, Anita |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/development-of-interpenetrating-microspheres-of-chitosan-and-gum-arabic-for-epigallocatechin-gallate-to-enhance-colonic-.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-06-28 | 2022-0930 | 2022-06-28 | 2022-06-28 | Articles Abstract Database |