Development of interpenetrating microspheres of chitosan and gum arabic for epigallocatechin gallate to enhance colonic delivery
By: Patel, N. C
.
Contributor(s): Patel, Anita.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(4), July-Aug.Description: 765-774p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Epigallocatechin gallate is a potent phytomolecule with wide biological activity and is a class III drug. The
therapeutic effect is limited, owing to poor stability and limited membrane permeability across the intestine.
The aim of this study was to develop and evaluate colon-targeted microspheres of epigallocatechin gallate,
using natural polymers. Water-in-oil emulsion crosslinking technique was used to prepare microspheres
of epigallocatechin gallate using interpenetrating network of chitosan and gum acacia and glutaraldehyde
was used as a crosslinking agent. Prepared microspheres were filled in capsules coated with Eudragit S100.
The prepared microspheres were evaluated in vitro for preformulation studies, encapsulation efficiency,
micromeritic properties, dissolution studies and stability studies. Fourier transform infrared spectroscopy
and differential scanning calorimetry studies had proved that the drug and polymers are compatible. The
good flow property of microspheres show that the microspheres are not aggregated. Scanning electron
microscope micrographs of microspheres show a rough and folded surface morphology. The microspheres
are spherical and uniform in shape. Formulations show good encapsulation efficiency. Formulation F1 to
F6 show sustained release of drug for 10 h. The in vitro drug release of batch F1 to F6 were best explained
by Higuchi models due to diffusion mechanism of drug release from polymeric matrix system. The selected
formulation batch for a period of 3 mo at 40±2°/75±5 % RH show no significant changes. The current
approach was helpful to develop polysaccharide based microspheres of epigallocatechin gallate to enhance
colonic drug delivery.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0930 |
Epigallocatechin gallate is a potent phytomolecule with wide biological activity and is a class III drug. The
therapeutic effect is limited, owing to poor stability and limited membrane permeability across the intestine.
The aim of this study was to develop and evaluate colon-targeted microspheres of epigallocatechin gallate,
using natural polymers. Water-in-oil emulsion crosslinking technique was used to prepare microspheres
of epigallocatechin gallate using interpenetrating network of chitosan and gum acacia and glutaraldehyde
was used as a crosslinking agent. Prepared microspheres were filled in capsules coated with Eudragit S100.
The prepared microspheres were evaluated in vitro for preformulation studies, encapsulation efficiency,
micromeritic properties, dissolution studies and stability studies. Fourier transform infrared spectroscopy
and differential scanning calorimetry studies had proved that the drug and polymers are compatible. The
good flow property of microspheres show that the microspheres are not aggregated. Scanning electron
microscope micrographs of microspheres show a rough and folded surface morphology. The microspheres
are spherical and uniform in shape. Formulations show good encapsulation efficiency. Formulation F1 to
F6 show sustained release of drug for 10 h. The in vitro drug release of batch F1 to F6 were best explained
by Higuchi models due to diffusion mechanism of drug release from polymeric matrix system. The selected
formulation batch for a period of 3 mo at 40±2°/75±5 % RH show no significant changes. The current
approach was helpful to develop polysaccharide based microspheres of epigallocatechin gallate to enhance
colonic drug delivery.
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