Effects of astragaloside on biological characteristics of non-small cell lung cancer cells via the phosphatidylinositol 3-kinase/protein kinase b/ mechanistic target of rapamycin pathway (Record no. 16947)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220628141617.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220628b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16889 |
| Author | Liu, Yuxia |
| 245 ## - TITLE STATEMENT | |
| Title | Effects of astragaloside on biological characteristics of non-small cell lung cancer cells via the phosphatidylinositol 3-kinase/protein kinase b/ mechanistic target of rapamycin pathway |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(4), July-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 865-870p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To evaluate the effects of astragaloside on the proliferation, invasion, migration and apoptosis of non- small cell lung cancer A549 cells and phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin pathway. After A549 cells were treated with 0, 10, 20, 40, 60, 80 and 100 μmol/l astragaloside for 24 h, the survival rate was measured by methyl thiazolyl tetrazolium assay and the half maximal inhibitory concentration was calculated. Astragaloside at half maximal inhibitory concentration was added. Cell invasion, migration and apoptosis were detected by transwell assay, wound healing assay and flow cytometry, respectively. The effects of astragaloside on the expressions of phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin pathway-related proteins were detected by western blotting. After different concentrations of astragaloside were added, cell proliferation declined with increasing concentration. Half maximal inhibitory concentration against A549 cell proliferation was 32.2 μmol/l. Compared with blank control group; cell proliferation; invasion and migration were significantly weakened, while apoptosis was enhanced in astragaloside group. The expressions of phosphorylation of phosphatidylinositol 3-kinase, phosphorylation of protein kinase B and phosphorylation of mechanistic target of rapamycin proteins in astragaloside group were significantly lower than those in blank control group. Astragaloside inhibits the proliferation, invasion and migration, and promotes the apoptosis of non- small cell lung cancer A549 cells dose-dependently. Inhibiting phosphorylation of phosphatidylinositol 3-kinase, phosphorylation of protein kinase B and phosphorylation of mechanistic target of rapamycin expressions in the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin pathway may be one of the mechanisms of astragaloside. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16890 |
| Co-Author | Zhao, Yue |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/effects-of-astragaloside-on-biological-characteristics-of-nonsmall-cell-lung-cancer-cells-via-the-phosphatidylinositol-3.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-06-28 | 2022-0940 | 2022-06-28 | 2022-06-28 | Articles Abstract Database |