Quercetin regulates inflammatory response of retinal ganglion cells by affecting the tumor necrosis factor receptor associated factor 6/transforming growth factor-β-activated kinase-1 signaling pathway (Record no. 17253)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220730162606.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220730b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17457 |
| Author | Deng, Zifeng |
| 245 ## - TITLE STATEMENT | |
| Title | Quercetin regulates inflammatory response of retinal ganglion cells by affecting the tumor necrosis factor receptor associated factor 6/transforming growth factor-β-activated kinase-1 signaling pathway |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1304-1308p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To investigate the protective effect of quercetin on the lipopolysaccharide-induced inflammatory response of retinal ganglion cell line 5 cells and to explore its possible molecular mechanism. Retinal ganglion cell line 5 cells were cultured in vitro and assigned into blank control group, lipopolysaccharide (1.0 μg/ml) induction group, lipopolysaccharide+low dose (0.25 μg/ml) quercetin group, lipopolysaccharide+medium dose (0.5 μg/ml) quercetin group and lipopolysaccharide+high dose (1.0 μg/ml) quercetin group. The relative survival rate of retinal ganglion cell line 5 cells was determined by cell counting kit-8 assay and the levels of inflammatory factors interleukin-6 and tumor necrosis factor-alpha were detected using enzyme- linked immunosorbent assay kits. In addition, the levels of tumor necrosis factor receptor-associated factor 6, phosphorylation-transforming growth factor-beta-activated kinase 1 and transforming growth factor- beta-activated kinase 1 were measured by western blotting. The results of cell counting kit-8 assay revealed that quercetin could dramatically elevate the relative survival rate of retinal ganglion cell line 5 cells. The levels of inflammatory factors interleukin-6 and tumor necrosis factor-alpha in different quercetin groups were significantly lower than those in lipopolysaccharide induction group and the levels of interleukin-6 and tumor necrosis factor-alpha in cell supernatant declined with the increase of quercetin concentration in a concentration-dependent manner. In addition, the expression levels of tumor necrosis factor receptor- associated factor 6 and phosphorylation-transforming growth factor-beta-activated kinase 1 in different quercetin groups were remarkably lower than those in lipopolysaccharide induction group and they also declined with the increase of quercetin concentration in a concentration-dependent manner. Quercetin displays a protective effect against the lipopolysaccharide-induced inflammatory response of retinal ganglion cell line 5 cells and its mechanism is related to suppression of the activation of the tumor necrosis factor receptor-associated factor 6/transforming growth factor-beta-activated kinase 1 signaling pathway. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17458 |
| Co-Author | Xiong, Shibo |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/quercetin-regulates-inflammatory-response-of-retinal-ganglion-cells-by-affecting-the-tumor-necrosis-factor-receptor-asso.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-07-30 | 2022-1255 | 2022-07-30 | 2022-07-30 | Articles Abstract Database |