Floating microspheres of lafutidine: formulation, optimization, characterization, in-vitro and in-vivo floatability studies using eudragit grades (Record no. 17323)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825133841.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220825b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 11968 |
| Author | Sunil Kumar |
| 245 ## - TITLE STATEMENT | |
| Title | Floating microspheres of lafutidine: formulation, optimization, characterization, in-vitro and in-vivo floatability studies using eudragit grades |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 681-688p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim/Background: The objective behind this study was to develop a Microspheres of Lafuditine using central composite design for gastroretentive drug delivery. Materials and Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation method. The present investigation will study the effect of formulation variables (polymer concentration etc) on the floating behaviour and drug release characteristics for developing mathematical relationship between them and optimize the formulation with an aim to minimize onset of floatation, maximize the duration of floatation in stomach in order to achieve maximum bioavailability and therapeutic efficacy of selected drug. Microspheres were evaluated for shape, size, melting point, buoyancy time, floating capacity, % yield, swelling index, and in-vitro drug release and in-vivo kinetic studies. Results: Results showed that selected independent variables significantly affect the yield (66-85%), particle size (3.78-10.62 μm), buoyancy (42.68-95.75%), encapsulation efficiency (69.32–94.05%), and cumulative drug release from the microspheres (79.02-96.92%). The interface and quadratic terms were also affect the process variables, it can be said that to develop and optimize gastroretentive system of Lafuditine with central composite design (CCD) is a valuable second-degree design which is effective treatment of H. pylori mediated infection and also provides a base to localize the drug release in the gastric region. Conclusion: The gastroretentive floating Microparticulate system of Lafutidine will enhance the patient compliance and play a vital role in improving patient’s quality of life. Keywords: Lafutidine, Eudragit, Central composite design, In-vitro drug release, Microparticulate system, Sodium bicarbonate. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4645 |
| Co-Author | Tiwari, Abhishek |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-681.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-25 | 2022-1373 | 2022-08-25 | 2022-08-25 | Articles Abstract Database |