Floating microspheres of lafutidine: formulation, optimization, characterization, in-vitro and in-vivo floatability studies using eudragit grades
By: Sunil Kumar
.
Contributor(s): Tiwari, Abhishek.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(3), Jul-Sep.Description: 681-688p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Aim/Background: The objective behind this study was to develop a Microspheres of
Lafuditine using central composite design for gastroretentive drug delivery. Materials and
Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation
method. The present investigation will study the effect of formulation variables (polymer
concentration etc) on the floating behaviour and drug release characteristics for developing
mathematical relationship between them and optimize the formulation with an aim to
minimize onset of floatation, maximize the duration of floatation in stomach in order to
achieve maximum bioavailability and therapeutic efficacy of selected drug. Microspheres
were evaluated for shape, size, melting point, buoyancy time, floating capacity, % yield,
swelling index, and
in-vitro drug release and in-vivo kinetic studies. Results: Results
showed that selected independent variables significantly affect the yield (66-85%),
particle size (3.78-10.62 μm), buoyancy (42.68-95.75%), encapsulation efficiency
(69.32–94.05%), and cumulative drug release from the microspheres (79.02-96.92%).
The interface and quadratic terms were also affect the process variables, it can be said
that to develop and optimize gastroretentive system of Lafuditine with central composite
design (CCD) is a valuable second-degree design which is effective treatment of
H. pylori
mediated infection and also provides a base to localize the drug release in the gastric
region. Conclusion: The gastroretentive floating Microparticulate system of Lafutidine will
enhance the patient compliance and play a vital role in improving patient’s quality of life.
Keywords: Lafutidine, Eudragit, Central composite design,
In-vitro drug release,
Microparticulate system, Sodium bicarbonate.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1373 |
Aim/Background: The objective behind this study was to develop a Microspheres of
Lafuditine using central composite design for gastroretentive drug delivery. Materials and
Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation
method. The present investigation will study the effect of formulation variables (polymer
concentration etc) on the floating behaviour and drug release characteristics for developing
mathematical relationship between them and optimize the formulation with an aim to
minimize onset of floatation, maximize the duration of floatation in stomach in order to
achieve maximum bioavailability and therapeutic efficacy of selected drug. Microspheres
were evaluated for shape, size, melting point, buoyancy time, floating capacity, % yield,
swelling index, and
in-vitro drug release and in-vivo kinetic studies. Results: Results
showed that selected independent variables significantly affect the yield (66-85%),
particle size (3.78-10.62 μm), buoyancy (42.68-95.75%), encapsulation efficiency
(69.32–94.05%), and cumulative drug release from the microspheres (79.02-96.92%).
The interface and quadratic terms were also affect the process variables, it can be said
that to develop and optimize gastroretentive system of Lafuditine with central composite
design (CCD) is a valuable second-degree design which is effective treatment of
H. pylori
mediated infection and also provides a base to localize the drug release in the gastric
region. Conclusion: The gastroretentive floating Microparticulate system of Lafutidine will
enhance the patient compliance and play a vital role in improving patient’s quality of life.
Keywords: Lafutidine, Eudragit, Central composite design,
In-vitro drug release,
Microparticulate system, Sodium bicarbonate.
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