Anticancer activity of grewia obtusa fruit on HCT- 116, MCF-7, and HeLa tumour cells besides antitubercular activity (Record no. 17335)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220826095138.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220826b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17611 |
| Author | Abdelaziz, Mazin Aboobaida Abdalla |
| 245 ## - TITLE STATEMENT | |
| Title | Anticancer activity of grewia obtusa fruit on HCT- 116, MCF-7, and HeLa tumour cells besides antitubercular activity |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 765-771p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and Objectives: Considering the unexplored therapeutic potential of a plant, Grewia obtusa (G. obtusa), and the study evaluated the biological potential of fruit extract for antitubercular and anticancer activities. Materials and Methods: G. obtusa fruit extracts were obtained by a process of cold maceration with the solvents, which includes methanol, ethyl acetate, and n-hexane. The phytochemical constituents were identified in the obtained three extracts by various qualitative tests and further screened for the activity of anticancer on HeLa, HCT- 116 and MCF-7 tumour cells, along with anti-tubercular activity against H37Rv Mycobacterium tuberculosis H37Rv Results: The results revealed that the presence of alkaloids, terpenes, lignans, carbohydrates, steroids, glycosides and flavonoids. Anticancer screening revealed the 3-4-fold efficacy of ethyl acetate extract (32.94 μg/ml) in inhibiting HCT-116 cells comparing to n-hexane (89.69 μg/ml) and methanol (128.86 μg/ml) extracts. Same result was notice on HeLa, for ethyl acetate extract with 4-5-fold potency (45.83 μg/ml) as compared to other test extracts of methanol (164.58 μg/ml) and n-hexane (194.58 μg/ml). In case of MCF-7 cell line also the GFE showed 2 to 3-fold potency (73.04 μg/ml) as compared to other test extracts of n-hexane (140.15 μg/ml) and methanol (251.79 μg/ml). The antitubercular activity showed the MIC of>200μg/ml for all extracts. Conclusion: Ethyl acetate extract exhibited more potent activity of inhibition on HCT- 116, MCF-7, and HeLa tumour cell lines than methanol and n-hexane extracts. In specifically G. obtusa fruit ethyl acetate extract was more active on HCT-116 tumour cell lines. But the antitubercular activity was not appreciable in all three extracts. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17612 |
| Co-Author | Dusthackeer, Vijayan N Azger |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-765.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-26 | 2022-1386 | 2022-08-26 | 2022-08-26 | Articles Abstract Database |