Amino acids from urine as possible biomarkers for early detection of vancomycin nephrotoxicity (Record no. 17339)
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fixed length control field | a |
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control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20220826115329.0 |
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fixed length control field | 220826b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 17618 |
Author | Nanaware, Harshal R. |
245 ## - TITLE STATEMENT | |
Title | Amino acids from urine as possible biomarkers for early detection of vancomycin nephrotoxicity |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.56(3), Jul-Sep |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Karnataka |
Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
Year | 2022 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 795-803p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Drug-induced nephrotoxicity is an important therapeutic concern, as many endogenous compounds are filtered through the kidneys for excretion into urine. Vancomycin is a drug of last resort used to treat multiple drug-resistant infections, and is primarily used in paediatrics to treat infections caused by gram-positive organisms resistant to beta-lactam antibiotics. Vancomycin is primarily (80–90%) excreted through the kidney. To identify biochemical markers useful for the early diagnosis of nephrotoxicity, amino acid profiling was performed in young Wistar rats treated with vancomycin. A liquid chromatography- mass spectrometry-based method was developed for targeted amino acid analysis from urine samples collected after dosing with vancomycin (300 mg/kg). Alterations in amino acids levels were observed in urine immediately after the first dosing, and increased in prominence during the course of treatment. Nephrotoxicity was confirmed using established methods such as histopathological evaluation and clinical chemistry analysis. Of note, a significant change in amino acid levels in urine was observed well before any noticeable increase in traditional markers. This suggests that quantification of amino acids from urine could be a good alternative to blood-based analysis in neonates and children as a strategy for the detection of kidney injury at an earlier stage than any existing methods. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
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9 (RLIN) | 17619 |
Co-Author | Moorkoth, Sudheer |
773 0# - HOST ITEM ENTRY | |
Title | Indian journal of pharmaceutical education and research |
Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
International Standard Serial Number | 0019-5464 |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-795.pdf |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-26 | 2022-1390 | 2022-08-26 | 2022-08-26 | Articles Abstract Database |