Identification of antioxidant and antidiabetic compounds in hedychium spicatum using TLC bioautography coupled with mass spectrometry and their in silico molecular docking studies (Record no. 17346)
[ view plain ]
000 -LEADER | |
---|---|
fixed length control field | a |
003 - CONTROL NUMBER IDENTIFIER | |
control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20220826153634.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 220826b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 17630 |
Author | Singh, Harjeet |
245 ## - TITLE STATEMENT | |
Title | Identification of antioxidant and antidiabetic compounds in hedychium spicatum using TLC bioautography coupled with mass spectrometry and their in silico molecular docking studies |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.56(3), Jul-Sep |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Karnataka |
Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
Year | 2022 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 830-837p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Background: Traditional system of medicine has been practised since a long time to cure various diseases. More than 60-80 percent people across the world use herbal medicine for their health care. In the present study, TLC-MS bioautography combined with DPPH, α-amylase and α-glucosidase bioassay were used to compare antidiabetic and antioxidant activities in hydro alcoholic extracts of H. spicatum and also explore in silico molecular docking studies. Materials and Methods: In this paper, hydro-alcoholic extract of H. spicatum was prepared, run TLC and performed TLC- MS bioautography to identify antidiabetic and antioxidant bioactive compounds. Results: HPTLC analysis showed there are 10 and 5 metabolites present at 254 nm and 366 nm respectively in H. spicatum. Further, TLC-MS bioautography studies isolate total two lead compounds such as quercetin and beta-sitosterol. Quercetin shows DPPH, α-amylase and α-glucosidase activity whereas beta sitosterol shows α amylase activity only. Conclusion: In conclusion, TLC-MS bioautography proved to be a good technique to evaluate the antidiabetic and antioxidant potential of plant extracts and will be useful for discovering new therapeutic regimens. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME | |
9 (RLIN) | 17631 |
Co-Author | Singh, Nardev |
773 0# - HOST ITEM ENTRY | |
Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
Title | Indian journal of pharmaceutical education and research |
International Standard Serial Number | 0019-5464 |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-830.pdf |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-26 | 2022-1396 | 2022-08-26 | 2022-08-26 | Articles Abstract Database |