Formulation and evaluation of bendamustine loaded polymeric nanoparticle (Record no. 17358)
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control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20220829141636.0 |
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fixed length control field | 220829b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 17653 |
Author | Telsang, Mallikarjun |
245 ## - TITLE STATEMENT | |
Title | Formulation and evaluation of bendamustine loaded polymeric nanoparticle |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.56(2), Apr-June |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Karnataka |
Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
Year | 2022 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 414-419p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal of delivering the medication to particular cancer cells. Materials and Procedures: The nanoparticles were prepared using simple coacervation technique with increasing concentrations of BSA. The nanoparticles were characterized for process yield, particle size, surface morphology, drug loading capacity (%), particle size distribution (Polydispersity index), in-vitro drug release. The drug release kinetics were studies using different dissolution models. The drug loading capacity of the produced nanoparticles varied from 10.4% to 19%. Formulation (F1) had a mean particle size of approximately 122.4 nm and polydispersivity index of 0.432 across the different compositions. Bendamustine nanoparticles exhibit sustained drug release with almost 51.8% bendamustine released in one day. The drug release kinetics follows Korsmeyer-Peppas model with a Fickian drug release mechanism. The Bendamustine nanoparticles were found to be stable for a month at 40±5C and 75±5% relative humidity. Conclusion: Bendamustine loaded BSA nanoparticles were developed which were found to exhibit a sustained drug release profile. Albumin based Bendamustine nanoparticles have the potential to be explored further for the better management of the cancer chemotherapy with reduced side effects. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
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9 (RLIN) | 17654 |
Co-Author | Pradeep, D. |
773 0# - HOST ITEM ENTRY | |
Title | Indian journal of pharmaceutical education and research |
Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
International Standard Serial Number | 0019-5464 |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-414.pdf |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-29 | 2022-1425 | 2022-08-29 | 2022-08-29 | Articles Abstract Database |