Antimicrobial, antioxidant and cytotoxic activities of different fractions obtained from endophyticfusarium solani F01 isolated in catharanthus roseus collected in vietnam (Record no. 17364)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830093656.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17664 |
| Author | Nguyen, Tu |
| 245 ## - TITLE STATEMENT | |
| Title | Antimicrobial, antioxidant and cytotoxic activities of different fractions obtained from endophyticfusarium solani F01 isolated in catharanthus roseus collected in vietnam |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 461-469p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Finding out the biological sources is essential for pharmaceutical field. Materials and Methods: Endophytic fungus was isolated from Catharanthus roseus originated in Vietnam and then identified by comparing, phylogeny analyzing its 18S sRNA sequence using Blast search and GenomeNet. The supernatant and sonicated mycelia were fractionated with methanol, ethyl acetate, hexane. All the fractions were used to test antimicrobial, antioxidant, cytotoxicity activities. Antimicrobial activities on Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Serratia marcescens ATCC 14756, Vibrio parahaemolyticus ATCC 17802, and Escherichia coli ATCC 25922 were performed by well diffusion method. In terms of antioxidant activities, reducing power and DPPH radical scavenging assay were done. The purification from methanol extract was performed. The purified compounds were used to test antioxidant activity. For cytotoxicity activity, sulforhodamine B assay was used to test the extracts and purified compounds on the breast cancer cell line (MCF-7). Results: Fusarium solani F01 was identified. The treated methanol extract from cell-free supernatant showed the highest activities and wider spectrum than ethyl acetate and hexane extracts. Mycelial extracts in these solvents did not show activities except ethyl acetate extract. The methanol crude extract from cell-free supernatant gave the higher reducing power (1.416 ± 0.067) than ascorbic acid (0.577 ± 0.01) while others were very low at the concentration (100 μg/ ml). Only methanol extract obtained from supernatant showed moderate scavenging activity when comparison of their IC50 (9.17 g/ml) with IC50 of ascorbic acid (1.28 g/ ml). Four compounds were obtained that showed antioxidant activities, but there was one purified compound showed low effects on MCF-7 while methanol extract gave the highest inhibition (80.34 ± 1.28). Conclusion: The study suggested fungus isolated from Catharanthus roseus could show and give many biological compounds that will be a potential source for pharmaceutical field. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17665 |
| Co-Author | Doan, Vinh |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-461.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-30 | 2022-1431 | 2022-08-30 | 2022-08-30 | Articles Abstract Database |