Modulation of oxidative stress induced cerebral ischemia in wistar rats by hydroalcoholic extract oftalinum triangulare (Record no. 17369)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830143311.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17673 |
| Author | Mathala, Nalini |
| 245 ## - TITLE STATEMENT | |
| Title | Modulation of oxidative stress induced cerebral ischemia in wistar rats by hydroalcoholic extract oftalinum triangulare |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 503-510p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Neuroprotection is one of considerable interest in search of novel therapies to improve ischemic brain damage in the present scenario. The objective of the present investigation is to study the actions of Talinum triangulare in cerebral ischemia/reperfusion induced oxidative stress in Wistar rats and in-vitro antioxidant actions. Methods: Four different groups of adult Wistar rats are selected for study where group III and group IV are treated for 15 days with TTE (200mg/kg, 400mg/kg) earlier to ischemia, on 16 th day rats are dissected through global cerebral ischemia by occlusion of unilateral common carotid artery, prior to the dissection animals are sedated with thiopentone and after ischemia induction that 30 min reperfusion was followed. Following the ischemic injury various parameters such as infarct size, SOD, MDA, CAT and GSH levels were assessed after 48hr of reperfusion. Results: Phytochemical screening of TTE indicated the presence of alkaloids, flavonoids, glycosides, carbohydrates, saponins, tannins and resins . TTE also showed a significant in-vitro antioxidant activity. Pre-treatment of TTE for 15 days prior to the ischemic-reperfusion, the results reported a huge reduction in reduction in infarct size, MDA levels and significant increase in SOD, CAT and GSH levels compared to ischemic control rats which was statistically significant. Conclusion: The present study showed that hydroalcoholic extract of TTE leaves showed a significant in-vitro and in-vivo antioxidant activity. The present investigation reported that Talinum triangulare leaves extract showed dose dependant cerebroprotective effect with the selected dose of TTE 200 mg/kg and 400 mg/kg. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17674 |
| Co-Author | Rao, Vijaya Bhaskara |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-503.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-30 | 2022-1442 | 2022-08-30 | 2022-08-30 | Articles Abstract Database |