Modulation of oxidative stress induced cerebral ischemia in wistar rats by hydroalcoholic extract oftalinum triangulare
By: Mathala, Nalini
.
Contributor(s): Rao, Vijaya Bhaskara.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-June.Description: 503-510p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Neuroprotection is one of considerable interest in search of novel therapies
to improve ischemic brain damage in the present scenario. The objective of the present
investigation is to study the actions of
Talinum triangulare in cerebral ischemia/reperfusion
induced oxidative stress in Wistar rats and
in-vitro antioxidant actions. Methods: Four
different groups of adult Wistar rats are selected for study where group III and group
IV are treated for 15 days with TTE (200mg/kg, 400mg/kg) earlier to ischemia, on
16 th day rats are dissected through global cerebral ischemia by occlusion of unilateral
common carotid artery, prior to the dissection animals are sedated with thiopentone and
after ischemia induction that 30 min reperfusion was followed. Following the ischemic
injury various parameters such as infarct size, SOD, MDA, CAT and GSH levels were
assessed after 48hr of reperfusion. Results: Phytochemical screening of TTE indicated
the presence of alkaloids, flavonoids, glycosides, carbohydrates, saponins, tannins and
resins
. TTE also showed a significant
in-vitro antioxidant activity. Pre-treatment of TTE
for 15 days prior to the ischemic-reperfusion, the results reported a huge reduction in
reduction in infarct size, MDA levels and significant increase in SOD, CAT and GSH levels
compared to ischemic control rats which was statistically significant. Conclusion: The
present study showed that hydroalcoholic extract of TTE leaves showed a significant
in-vitro and in-vivo antioxidant activity. The present investigation reported that
Talinum
triangulare leaves extract showed dose dependant cerebroprotective effect with the
selected dose of TTE 200 mg/kg and 400 mg/kg.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1442 |
Background: Neuroprotection is one of considerable interest in search of novel therapies
to improve ischemic brain damage in the present scenario. The objective of the present
investigation is to study the actions of
Talinum triangulare in cerebral ischemia/reperfusion
induced oxidative stress in Wistar rats and
in-vitro antioxidant actions. Methods: Four
different groups of adult Wistar rats are selected for study where group III and group
IV are treated for 15 days with TTE (200mg/kg, 400mg/kg) earlier to ischemia, on
16 th day rats are dissected through global cerebral ischemia by occlusion of unilateral
common carotid artery, prior to the dissection animals are sedated with thiopentone and
after ischemia induction that 30 min reperfusion was followed. Following the ischemic
injury various parameters such as infarct size, SOD, MDA, CAT and GSH levels were
assessed after 48hr of reperfusion. Results: Phytochemical screening of TTE indicated
the presence of alkaloids, flavonoids, glycosides, carbohydrates, saponins, tannins and
resins
. TTE also showed a significant
in-vitro antioxidant activity. Pre-treatment of TTE
for 15 days prior to the ischemic-reperfusion, the results reported a huge reduction in
reduction in infarct size, MDA levels and significant increase in SOD, CAT and GSH levels
compared to ischemic control rats which was statistically significant. Conclusion: The
present study showed that hydroalcoholic extract of TTE leaves showed a significant
in-vitro and in-vivo antioxidant activity. The present investigation reported that
Talinum
triangulare leaves extract showed dose dependant cerebroprotective effect with the
selected dose of TTE 200 mg/kg and 400 mg/kg.
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