Study on the mechanism of soothing liver mixture against liver injury induced by antituberculosis drugs through lipopolysaccharide/toll-like receptor 4/nuclear factor kappa b signal pathway (Record no. 18307)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221121131343.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221121b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19189 |
| Author | Liu, Liqin |
| 245 ## - TITLE STATEMENT | |
| Title | Study on the mechanism of soothing liver mixture against liver injury induced by antituberculosis drugs through lipopolysaccharide/toll-like receptor 4/nuclear factor kappa b signal pathway |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.84(2), Mar-Apr |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 311-318p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Based on plasma endotoxin/toll-like receptor-4/nuclear factor-kappa B signal pathway to investigate the protective effect of soothing liver mixture on mice with liver injury induced by antituberculosis drugs. A total of 72 Sprague Dawley male rats were randomly divided into blank control group, model group, silymarin group and soothing liver mixture group (low, medium and high dosage), with 12 rats in each group. 16 h after the last administration, the pathological changes of liver tissue were observed by hematoxylin eosin staining; blood samples were taken from eyeball to detect liver function indexes (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase) oxidative stress indexes (superoxide dismutase, malondialdehyde, glutathione peroxidase) and inflammatory factors (interleukin- 1beta, interleukin-6, tumor necrosis factor-alpha) and the content of plasma endotoxin in plasma; the microRNA expression levels of toll-like receptor-4 and nuclear factor-kappa B in rat liver were detected by real time reverse transcription–polymerase chain reaction. Soothing liver mixture can alleviate hepatocyte injury, effectively improve liver function in rats, attenuate oxidative stress and inflammatory reactions in the body, reduce plasma endotoxin content and inhibit hepatic toll-like receptor-4 and nuclear factor- kappa B microRNA and protein expression, the higher the drug dose, the better the silymarin was similar to the high dose soothing liver mixture efficacy. Soothing liver mixture has a better protective effect on rats with liver injury induced by antituberculosis drugs; the mechanism may involve the regulation of plasma endotoxin/toll-like receptor-4/nuclear factor-kappa B signaling pathway the alleviation of the body's oxidative stress and inflammatory reaction. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19191 |
| Co-Author | Hu, X. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/study-on-the-mechanism-of-soothing-liver-mixture-against-liver-injury-induced-by-antituberculosis-drugs-through-lipopoly.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-11-21 | 2022-2172 | 2022-11-21 | 2022-11-21 | Articles Abstract Database |