Study on the mechanism of soothing liver mixture against liver injury induced by antituberculosis drugs through lipopolysaccharide/toll-like receptor 4/nuclear factor kappa b signal pathway
By: Liu, Liqin
.
Contributor(s): Hu, X.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 311-318p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Based on plasma endotoxin/toll-like receptor-4/nuclear factor-kappa B signal pathway to investigate
the protective effect of soothing liver mixture on mice with liver injury induced by antituberculosis
drugs. A total of 72 Sprague Dawley male rats were randomly divided into blank control group, model
group, silymarin group and soothing liver mixture group (low, medium and high dosage), with 12 rats
in each group. 16 h after the last administration, the pathological changes of liver tissue were observed
by hematoxylin eosin staining; blood samples were taken from eyeball to detect liver function indexes
(alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase) oxidative stress indexes
(superoxide dismutase, malondialdehyde, glutathione peroxidase) and inflammatory factors (interleukin-
1beta, interleukin-6, tumor necrosis factor-alpha) and the content of plasma endotoxin in plasma; the
microRNA expression levels of toll-like receptor-4 and nuclear factor-kappa B in rat liver were detected by
real time reverse transcription–polymerase chain reaction. Soothing liver mixture can alleviate hepatocyte
injury, effectively improve liver function in rats, attenuate oxidative stress and inflammatory reactions
in the body, reduce plasma endotoxin content and inhibit hepatic toll-like receptor-4 and nuclear factor-
kappa B microRNA and protein expression, the higher the drug dose, the better the silymarin was similar
to the high dose soothing liver mixture efficacy. Soothing liver mixture has a better protective effect on rats
with liver injury induced by antituberculosis drugs; the mechanism may involve the regulation of plasma
endotoxin/toll-like receptor-4/nuclear factor-kappa B signaling pathway the alleviation of the body's
oxidative stress and inflammatory reaction.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2172 |
Based on plasma endotoxin/toll-like receptor-4/nuclear factor-kappa B signal pathway to investigate
the protective effect of soothing liver mixture on mice with liver injury induced by antituberculosis
drugs. A total of 72 Sprague Dawley male rats were randomly divided into blank control group, model
group, silymarin group and soothing liver mixture group (low, medium and high dosage), with 12 rats
in each group. 16 h after the last administration, the pathological changes of liver tissue were observed
by hematoxylin eosin staining; blood samples were taken from eyeball to detect liver function indexes
(alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase) oxidative stress indexes
(superoxide dismutase, malondialdehyde, glutathione peroxidase) and inflammatory factors (interleukin-
1beta, interleukin-6, tumor necrosis factor-alpha) and the content of plasma endotoxin in plasma; the
microRNA expression levels of toll-like receptor-4 and nuclear factor-kappa B in rat liver were detected by
real time reverse transcription–polymerase chain reaction. Soothing liver mixture can alleviate hepatocyte
injury, effectively improve liver function in rats, attenuate oxidative stress and inflammatory reactions
in the body, reduce plasma endotoxin content and inhibit hepatic toll-like receptor-4 and nuclear factor-
kappa B microRNA and protein expression, the higher the drug dose, the better the silymarin was similar
to the high dose soothing liver mixture efficacy. Soothing liver mixture has a better protective effect on rats
with liver injury induced by antituberculosis drugs; the mechanism may involve the regulation of plasma
endotoxin/toll-like receptor-4/nuclear factor-kappa B signaling pathway the alleviation of the body's
oxidative stress and inflammatory reaction.
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