Erythrocyte morphology, osmotic fragility and hematological studies after short term dietary copper deficiency in male wistar rats (Record no. 18349)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221125120138.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221125b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19247 |
| Author | Saini, A. |
| 245 ## - TITLE STATEMENT | |
| Title | Erythrocyte morphology, osmotic fragility and hematological studies after short term dietary copper deficiency in male wistar rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.84(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 27-34p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Trace element copper is involved in myriad of physiological activities vital for normal function of organs of animals and humans from fetal development onwards. Its deficiency might occur in infants, children as well as adults and has been reported as a global problem affecting developed and undeveloped countries. Copper is essential for efficient iron uptake and mobilization. The present study evaluates the effect of dietary copper deficiency on erythrocyte of prepubertal male Wistar rats for 2, 4 and 6 w. Erythrocyte morphology, osmotic fragility, hematological parameters-hemoglobin, total leukocyte count, cell count (neutrophil, lymphocytes monocytes, eosinophils, platelets), packed cell volume, total red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration were evaluated. Occurrence of stomatocytes, echinocytes, dracocytes, acanthocytes, Howell-Jolly inclusion, microcyte and macrocytes were observed after 2 and 4 w of copper deficiency when compared with their respective control and pair fed groups. The extent of morphological changes enhanced after 6 w of dietary copper deficiency with additional appearance of fragmented cells and few elongated cells. The percentage of altered erythrocyte morphology after 2 w deficiency was 0.051 % which enhanced subsequently as duration increased to 0.081 % (4 w) and 0.1709 % (6 w). Consequent to these changes significant (p<0.05) increase in erythrocyte osmotic fragility, eosinophil and lymphocyte count was observed while hemoglobin, neutrophil and platelet count, packed cell volume, total red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration decreased. Monocyte decrease was not significant. These changes were more pronounced after 4 and 6 w. Dietary copper insufficiency caused impairment of membrane, deregulation of hematopoiesis and altered the hematological profile indicating detrimental changes in properties of cellular membrane which may probably be due to enhanced oxidative stress. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19248 |
| Co-Author | Kurup, A. R. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/erythrocyte-morphology-osmotic-fragility-and-hematological-studies-after-short-term-dietary-copper-deficiency-in-male-wi.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-11-25 | 2022-2215 | 2022-11-25 | 2022-11-25 | Articles Abstract Database |