Experimental design approach for validation and optimisation of spectrophotometric determination of cefixime in pharmaceutical dosage form (Record no. 18365)
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control field | OSt |
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control field | 20221128165035.0 |
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fixed length control field | 221128b xxu||||| |||| 00| 0 eng d |
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Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
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9 (RLIN) | 19273 |
Author | Basavaraj, H. |
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Title | Experimental design approach for validation and optimisation of spectrophotometric determination of cefixime in pharmaceutical dosage form |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.84(1), Jan-Feb |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Mumbai |
Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
Year | 2022 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 115-120p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Two simple, sensitive and precise spectrophotometric methods for the assay of cefixime in either pure form or in its pharmaceutical dosage form are described. The method I is based on the reaction of salicylaldehyde with cefixime resulting in a yellow coloured product, absorbs at λmax 425 nm. The second method describes the reaction between the diazotized drug and N-(1-naphthyl)ethylenediamine dihydrochloride to yield a purple coloured product with λmax at 567 nm. The reaction conditions were optimized to get maximum colour intensity. The absorbance was found to extend linearly with increasing the concentration of cefixime the systems obeyed the Beer’s law within the range of 2-10 μg/ml and 5-25 μg/ml for salicylaldehyde and N-(1-naphthyl)ethylenediamine dihydrochloride methods. Common excipients used as additives in pharmaceutical dosage don’t interfere within the proposed analytical methods. The products are stable for over 6 h and 10 h respectively. The proposed methods are simple, sensitive, accurate and suitable for quality control uses. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
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9 (RLIN) | 19274 |
Co-Author | Mruthyunjayaswamy, B. H. M. |
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Place, publisher, and date of publication | New Delhi |
Title | Indian journal of pharmaceutical sciences |
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URL | https://www.ijpsonline.com/articles/an-experimental-design-approach-for-validation-and-optimisation-of-spectrophotometric-determination-of-cefixime-in-pharm.pdf |
Link text | Click here |
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Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2022-11-28 | 2022-2244 | 2022-11-28 | 2022-11-28 | Articles Abstract Database |