000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20181204152752.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
181204b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
6559 |
Author |
Anerao, A. |
245 ## - TITLE STATEMENT |
Title |
HPLC Determination of n-methylethanolamine in diphenhydramine hydrochloride drug substance by pre- |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol. 55 (10) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Mumbai |
Name of publisher, distributor, etc. |
Indian Drug Manufacture's Association - IDMA |
Year |
2018 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
56-62 |
520 ## - SUMMARY, ETC. |
Summary, etc. |
N-Methylethanolamine is the side chain of the drug diphenhydramine hydrochloride. A sensitive high performance liquid chromatography method with pre-column derivatization was developed and validated for the determination of N-methylethanolamine impurity in diphenhydramine hydrochloride active pharmaceutical ingredient. HPLC method on column Cosmosil MS-II, C-18, 250 mm X 4.6 mm, particle size 5 μm with UV detector was used. The proposed method is specific, linear, accurate, rugged and precise. The calibration curves showed good linearity over the concentration range of 0.03 mg/g to 1.5 mg/g and the correlation coefficient was 0.999. Method had very low limit of detection (LOD) and limit of quantification (LOQ) as 0.01 mg/g and 0.03 mg/g, respectively, of the analyte. Accuracy was observed within 94.4% to 96.2%. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
653 ## - Keywords |
Keywords |
Derivatization |
-- |
validation |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
6561 |
Co-Author |
Dighe, V. |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
6562 |
Co-Author |
Gupta, A. |
773 0# - HOST ITEM ENTRY |
Title |
Indian drugs |
Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |