PHYSICOCHEMICAL CHARACTERISTICS OF RASAMANIKYA -AN AYURVEDIC ARSENICAL FORMULATION
By: Singh, Arjun
.
Contributor(s): Ota, Sarada.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(5).Description: 31-36p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
The objective
of this study was standardization and Chemical char
acterization of
rasamanikya
prepared as per standard operating
procedures (SOP) mentioned in the classical text.
Methods:
Rasamanikya
was prepared by putting
churnodaka
shodhita haratala
(Orpiment-As
2
S
3
) between two
abhraka
(white mica) sheets which
are heated for a while to obtain a red colored fini
shed product. The Ayurvedic specifications for the
analysis of
rasamanikya
were performed
through qualitative and quantitative analysis. Phys
icochemical analysis, assay of elements by atomic a
bsorption spectrometer (AAS) and inductively
coupled plasma-atomic emission spectrometry (ICP-AE
S) were carried out and some other tests such as x-
ray diffraction (XRD), x-ray photoelectron
spectroscopy (XPS) and energy dispersive x-ray anal
yzer (EDAX) were also performed to ensure the quali
ty of the drug.
Results:
In the finished drug Arsenic and Sulphur are presen
t in the form of As
4
S
4
, As
2
S
3
, As
2
S
5
. On the basis of XPS survey scans, scanning electr
on
microscopy-energy dispersive x-ray analyzer (SEM-ED
AX) and carbon, hydrogen, nitrogen, sulphur (CHNS) a
nalysis the Arsenic to Sulphur (As to S)
ratio is thus standardized as 39-47: 53-61. In addi
tion to this powder, XRD shows a major conversion i
nto an amorphous phase.
Conclusion:
The results could be used to lay down a new set of
pharmacopoeial standards for the preparation of
rasamanikya
for getting optimal
efficacy of medicine. Therefore, the information wi
ll help the Scientists and Researchers to build com
prehensive standards, to screen the
compounds responsible for different bioactivities,
and to elucidate the molecular mechanism of action.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020924 |
Objective:
The objective
of this study was standardization and Chemical char
acterization of
rasamanikya
prepared as per standard operating
procedures (SOP) mentioned in the classical text.
Methods:
Rasamanikya
was prepared by putting
churnodaka
shodhita haratala
(Orpiment-As
2
S
3
) between two
abhraka
(white mica) sheets which
are heated for a while to obtain a red colored fini
shed product. The Ayurvedic specifications for the
analysis of
rasamanikya
were performed
through qualitative and quantitative analysis. Phys
icochemical analysis, assay of elements by atomic a
bsorption spectrometer (AAS) and inductively
coupled plasma-atomic emission spectrometry (ICP-AE
S) were carried out and some other tests such as x-
ray diffraction (XRD), x-ray photoelectron
spectroscopy (XPS) and energy dispersive x-ray anal
yzer (EDAX) were also performed to ensure the quali
ty of the drug.
Results:
In the finished drug Arsenic and Sulphur are presen
t in the form of As
4
S
4
, As
2
S
3
, As
2
S
5
. On the basis of XPS survey scans, scanning electr
on
microscopy-energy dispersive x-ray analyzer (SEM-ED
AX) and carbon, hydrogen, nitrogen, sulphur (CHNS) a
nalysis the Arsenic to Sulphur (As to S)
ratio is thus standardized as 39-47: 53-61. In addi
tion to this powder, XRD shows a major conversion i
nto an amorphous phase.
Conclusion:
The results could be used to lay down a new set of
pharmacopoeial standards for the preparation of
rasamanikya
for getting optimal
efficacy of medicine. Therefore, the information wi
ll help the Scientists and Researchers to build com
prehensive standards, to screen the
compounds responsible for different bioactivities,
and to elucidate the molecular mechanism of action.
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