In vivo Immunomodulatory Potential of Aqueous Extract of Different Parts of Terminalia catappa L.
By: VENKATALAKSHMI, P
.
Contributor(s): BRINDHA, P.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(3), May-June.Description: 584-593p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Modulation of immunity is the most sought therapeutic effect as many human ailments arise because of
imbalance in immune mechanisms. In the current corona virus disease scenarios also, the role of immunity
to combat the dreadful virus has been well emphasized. Hence the present study aims at evaluating the
immunomodulatory potential of aqueous extract obtained from the different parts such as bark, fruit and
wood of Terminalia catappa. Based on the results obtained in acute oral toxicity and dose fixation studies,
medium dose (250 mg/kg body weight) of selected plant extracts were administered for 14 d to swiss albino
mice to evaluate nonspecific (neutrophil adhesion, phagocytic index) and specific (hemagglutination
antibody titer, delayed type hypersensitivity) immunomodulatory properties. The results obtained for
plant extract treated groups were compared with cyclophosphamide (immunosuppressant) treated and
levamisole (immunostimulant) treated mice. From the data of the results obtained it could be concluded
that selected parts ofTerminalia catappa have immune stimulatory as well as anti-inflammatory properties,
thereby proving their efficacy as true immunomodulators. Among the parts selected, fruits exhibited
significant immunomodulatory potential followed by bark and wood.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022571 |
Modulation of immunity is the most sought therapeutic effect as many human ailments arise because of
imbalance in immune mechanisms. In the current corona virus disease scenarios also, the role of immunity
to combat the dreadful virus has been well emphasized. Hence the present study aims at evaluating the
immunomodulatory potential of aqueous extract obtained from the different parts such as bark, fruit and
wood of Terminalia catappa. Based on the results obtained in acute oral toxicity and dose fixation studies,
medium dose (250 mg/kg body weight) of selected plant extracts were administered for 14 d to swiss albino
mice to evaluate nonspecific (neutrophil adhesion, phagocytic index) and specific (hemagglutination
antibody titer, delayed type hypersensitivity) immunomodulatory properties. The results obtained for
plant extract treated groups were compared with cyclophosphamide (immunosuppressant) treated and
levamisole (immunostimulant) treated mice. From the data of the results obtained it could be concluded
that selected parts ofTerminalia catappa have immune stimulatory as well as anti-inflammatory properties,
thereby proving their efficacy as true immunomodulators. Among the parts selected, fruits exhibited
significant immunomodulatory potential followed by bark and wood.
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