Comparison of pregabalin and nortriptyline on sleep, quality of life in postherpetic neuralgia: a prospective, randomised, open-label, parallel study
By: Khajuria, Kanika
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Contributor(s): Gupta, Seema.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2021Edition: Vol.13(6).Description: 27-30p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:Aim of the present study was to compare the effectsof pregabalinand nortriptyline onsleep and qualityof life in patients of postherpetic neuralgia (PHN).Methods: The present study was conducted in48patients of PHN attending the outpatient department (OPD)of Dermatology, Government Medical College Jammu. Based oninclusion/exclusion criteria patients were randomized into two treatment groups.One group received pregabalin 150 mg/day and the other group was treated with nortriptyline25 mg/day. The patientswere followed upto eightweeks and assessed for Sleep (Medical Outcomes Study sleep scale)and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC)scoreand Patient Global Impression of Change(PGIC)score were used toevaluate overall clinical improvement.Results:Both drugs significantly improved all parametersstudied (p<0.0001).On comparison,both drugs had similar effectson sleep and quality of life.However, pregabalinwas found to be better than nortriptyline at eight weeksonCGIC (p<0.004) and PGIC (p<0.0003)scores.Conclusion:Both pregabalin and nortriptyline wereequallyeffectivein improving sleep and quality of life.Overall clinical improvement was better with pregabalin than nortriptyline at eight weeks
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022648 |
Objective:Aim of the present study was to compare the effectsof pregabalinand nortriptyline onsleep and qualityof life in patients of postherpetic neuralgia (PHN).Methods: The present study was conducted in48patients of PHN attending the outpatient department (OPD)of Dermatology, Government Medical College Jammu. Based oninclusion/exclusion criteria patients were randomized into two treatment groups.One group received pregabalin 150 mg/day and the other group was treated with nortriptyline25 mg/day. The patientswere followed upto eightweeks and assessed for Sleep (Medical Outcomes Study sleep scale)and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC)scoreand Patient Global Impression of Change(PGIC)score were used toevaluate overall clinical improvement.Results:Both drugs significantly improved all parametersstudied (p<0.0001).On comparison,both drugs had similar effectson sleep and quality of life.However, pregabalinwas found to be better than nortriptyline at eight weeksonCGIC (p<0.004) and PGIC (p<0.0003)scores.Conclusion:Both pregabalin and nortriptyline wereequallyeffectivein improving sleep and quality of life.Overall clinical improvement was better with pregabalin than nortriptyline at eight weeks
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