Evaluationofanti-inflammatoryactivityofmacroalgaecollectedfrombajacaliforniasur,Mexico
By: García-López, Elena Berenice
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Contributor(s): Muñoz-Ochoa, Mauricio.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2021Edition: Vol.13(8).Description: 81-88p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:This study aimed to establish the anti-inflammatory potential of macroalgae from Baja California Sur, Mexico. Methods: The anti-inflammatory activity of the extracts from 10 macroalgae species was evaluatedin vitro and in vivo. Dichloromethane, ethanolic, and aqueous extracts were obtained from each species. The criteria used to determine anti-inflammatory activity included 1) the membrane protection of human red blood cells (HRBCs) against hemolysis induced by hypotonicity, 2) the inhibition of heat-induced protein denaturation (IDP), and 3) the inhibition of mouse ear edema and the myeloperoxidase (MPO) enzyme.Results:The dichloromethane extracts of Gracilaria vermiculophyllaand Opuntiella californica were the most active, both in vitro and in vivo. Theseextracts resulted in values of HRBC membrane protection above 95%, which were similar to those obtained with diclofenac sodium. And reduce the inflammation with edema inhibition percentage up to 60 % while the control indomethacin was able to inhibit edema by 82.3 %. Conclusion:The bioprospection of several macroalgae species from Bahía de La Paz, Mexico, allowed the identification of two species withpromising anti-inflammatory activity. Gracilaria vermiculophyllashowed interesting topical anti-inflammatory effects and a profile of compounds(flavonoids and terpenes) that may contribute to the potential biological properties of this seaweed. This study represents the first report of the anti-inflammatory potential of O. californica.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0417 |
Objective:This study aimed to establish the anti-inflammatory potential of macroalgae from Baja California Sur, Mexico. Methods: The anti-inflammatory activity of the extracts from 10 macroalgae species was evaluatedin vitro and in vivo. Dichloromethane, ethanolic, and aqueous extracts were obtained from each species. The criteria used to determine anti-inflammatory activity included 1) the membrane protection of human red blood cells (HRBCs) against hemolysis induced by hypotonicity, 2) the inhibition of heat-induced protein denaturation (IDP), and 3) the inhibition of mouse ear edema and the myeloperoxidase (MPO) enzyme.Results:The dichloromethane extracts of Gracilaria vermiculophyllaand Opuntiella californica were the most active, both in vitro and in vivo. Theseextracts resulted in values of HRBC membrane protection above 95%, which were similar to those obtained with diclofenac sodium. And reduce the inflammation with edema inhibition percentage up to 60 % while the control indomethacin was able to inhibit edema by 82.3 %. Conclusion:The bioprospection of several macroalgae species from Bahía de La Paz, Mexico, allowed the identification of two species withpromising anti-inflammatory activity. Gracilaria vermiculophyllashowed interesting topical anti-inflammatory effects and a profile of compounds(flavonoids and terpenes) that may contribute to the potential biological properties of this seaweed. This study represents the first report of the anti-inflammatory potential of O. californica.
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