MicroRNA-142-5p suppresses proliferation and invasion of non-small cell lung cancer cells by targeting programmed cell death receptor ligand 1
By: Gao, Jing
.
Contributor(s): Li, S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(4), July-Aug.Description: 742-749p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Lung cancer is one of the most deadly tumor disease in the world and most lung cancer is non-small cell
lung cancer. MicroRNAs are considered as a variety of endogenous non-coding RNA, acting as interference
during the process after transcription of gene. Recently, microRNA-142-5p, one of the microRNAs,
was reported to enhance anti-tumor immune response of non-small cell lung cancer cells by targeting
programmed cell death receptor ligand 1. Programmed cell death receptor ligand 1 was also believed to be
a regulator of cell proliferation and migration. However, the effect of microRNA-142-5p on proliferation
and invasion of non-small cell lung cancer cells via regulating programmed cell death receptor ligand 1
was still unknown. Thus, this study demonstrated that there was low expression level of microRNA-142-
5p in different non-small cell lung cancer cell lines. Programmed cell death receptor ligand 1 was proved
to be the target gene of microRNA-142-5p and microRNA-142-5p also had negative correlation with
programmed cell death receptor ligand 1. The high expression of microRNA-142-5p lead to suppression of
proliferation and invasion in non-small cell lung cancer cells by down regulation of programmed cell death
receptor ligand 1. The mechanism of microRNA-142-5p affecting proliferation and invasion of non-small
cell lung cancer cells via targeting programmed cell death receptor ligand 1 might give a new thought of
tumor therapy.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0923 |
Lung cancer is one of the most deadly tumor disease in the world and most lung cancer is non-small cell
lung cancer. MicroRNAs are considered as a variety of endogenous non-coding RNA, acting as interference
during the process after transcription of gene. Recently, microRNA-142-5p, one of the microRNAs,
was reported to enhance anti-tumor immune response of non-small cell lung cancer cells by targeting
programmed cell death receptor ligand 1. Programmed cell death receptor ligand 1 was also believed to be
a regulator of cell proliferation and migration. However, the effect of microRNA-142-5p on proliferation
and invasion of non-small cell lung cancer cells via regulating programmed cell death receptor ligand 1
was still unknown. Thus, this study demonstrated that there was low expression level of microRNA-142-
5p in different non-small cell lung cancer cell lines. Programmed cell death receptor ligand 1 was proved
to be the target gene of microRNA-142-5p and microRNA-142-5p also had negative correlation with
programmed cell death receptor ligand 1. The high expression of microRNA-142-5p lead to suppression of
proliferation and invasion in non-small cell lung cancer cells by down regulation of programmed cell death
receptor ligand 1. The mechanism of microRNA-142-5p affecting proliferation and invasion of non-small
cell lung cancer cells via targeting programmed cell death receptor ligand 1 might give a new thought of
tumor therapy.
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