Recent development in nuclear magnetic resonance as a technique for quantitative method validation
By: Sahu, R
.
Contributor(s): Kumar, A.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(6), Nov-Dec.Description: 1094-1106p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Nuclear magnetic resonance spectroscopy has largely given way for most important routine analysis
of natural, synthetic drug candidate and related molecules. The quality control and simultaneous
quantitation of different residual solvents, analytes and impurities have led analysts to further exploit
nuclear magnetic resonance as a viable quantitative technique. Hence, this review focuses on the use
and feasibility of this technique for quantitative method validation of drug and related compounds.
Validated quantitative nuclear magnetic resonance methods were simple, robust, accurate and selective
for evaluating different natural and synthetic samples using various commercially accessible compounds
as internal standards. In this review numerous examples are cited giving proof of advancement in nuclear
magnetic resonance technology and also for precise evaluation of molecular structures of substances in
solids and liquid. Studied examples of different concurrent validation methods in the review shows that
the results obtained is precise with less standard deviation when compared with other chromatography
techniques. Concluding the entire review, various methodologies used for quantification and validations
were reflected that proved to be a specific, selective and alternative means of method validation and it can
be summarized that nuclear magnetic resonance is as reliable as the chromatography-based technique for
quantitative analysis providing accuracy.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-1218 |
Nuclear magnetic resonance spectroscopy has largely given way for most important routine analysis
of natural, synthetic drug candidate and related molecules. The quality control and simultaneous
quantitation of different residual solvents, analytes and impurities have led analysts to further exploit
nuclear magnetic resonance as a viable quantitative technique. Hence, this review focuses on the use
and feasibility of this technique for quantitative method validation of drug and related compounds.
Validated quantitative nuclear magnetic resonance methods were simple, robust, accurate and selective
for evaluating different natural and synthetic samples using various commercially accessible compounds
as internal standards. In this review numerous examples are cited giving proof of advancement in nuclear
magnetic resonance technology and also for precise evaluation of molecular structures of substances in
solids and liquid. Studied examples of different concurrent validation methods in the review shows that
the results obtained is precise with less standard deviation when compared with other chromatography
techniques. Concluding the entire review, various methodologies used for quantification and validations
were reflected that proved to be a specific, selective and alternative means of method validation and it can
be summarized that nuclear magnetic resonance is as reliable as the chromatography-based technique for
quantitative analysis providing accuracy.
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