Protective effects of ficus benghalensis in streptozotocin (STZ) induced diabetic zebrafish (Danio rerio) model
By: Sabi, Essa M
.
Contributor(s): Mujamammi, Ahmed H.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(3), Jul-Sep.Description: 822-829p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized
by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy,
nephropathy, and retinopathy are associated with DM. Objectives: To explore a
safer treatment option with no/less adverse effects, we evaluated the potential of
Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods:
Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After
induction,
Ficus benghalensis hydroethanolic bark extract was administered to zebrafish
in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such
as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as
alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were
analyzed. Results: Treating the streptozotocin-induced group with
Ficus benghalensis
hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides,
and liver enzymes. The histopathological evaluation also showed improvement in the
damaged pancreatic tissues. Conclusion: Our results suggest that
Ficus benghalensis
hydroethanolic bark extract can be used as a potent therapeutic candidate for treating
diabetes.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1395 |
Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized
by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy,
nephropathy, and retinopathy are associated with DM. Objectives: To explore a
safer treatment option with no/less adverse effects, we evaluated the potential of
Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods:
Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After
induction,
Ficus benghalensis hydroethanolic bark extract was administered to zebrafish
in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such
as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as
alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were
analyzed. Results: Treating the streptozotocin-induced group with
Ficus benghalensis
hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides,
and liver enzymes. The histopathological evaluation also showed improvement in the
damaged pancreatic tissues. Conclusion: Our results suggest that
Ficus benghalensis
hydroethanolic bark extract can be used as a potent therapeutic candidate for treating
diabetes.
Click on an image to view it in the image viewer
There are no comments for this item.