Anti-inflammatory effects of sargassum muticum ethanol extract in lipopolysaccharide-induced raw 264.7 cells and mouse ear edema models
By: Jeong, S. M
.
Contributor(s): Kim, M. J.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 230-238p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: This study investigated the effects and the anti-inflammatory activity of Sargassum muticum ethanol
extract in lipopolysaccharide-induced RAW 264.7 murine macrophage cells and in a croton oil-induced
mouse ear edema model. Pretreatment of lipopolysaccharide-induced RAW 264.7 cells with Sargassum
muticum ethanol extract (0.1-100 μg/ml) inhibited lipopolysaccharide-induced production of nitric
oxide, interleukin-6 and tumour necrosis factor alpha in a dose-dependent manner. The expression of
lipopolysaccharide-induced, inducible nitric oxide synthase and cyclooxygenase-2 in the Sargassum
muticum ethanol extract-treated group was also suppressed in a dose-dependent manner. Furthermore, we
found that Sargassum muticum ethanol extract induced anti-inflammatory effects by inhibiting Mitogen-
activated protein kinases (extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38) and
nuclear factor kappa B, p65 phosphorylation in lipopolysaccharide-stimulated RAW 264.7 cells. The anti-
inflammatory activity of Sargassum muticum ethanol extract in vivo was evaluated in the ear edema model
of a croton oil-treated mouse. Compared to the untreated control, croton oil-induced ear edema was found
to be reduced by about 33 % upon treatment with 250 mg/kg Sargassum muticum ethanol extract.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2259 |
This study investigated the effects and the anti-inflammatory activity of Sargassum muticum ethanol
extract in lipopolysaccharide-induced RAW 264.7 murine macrophage cells and in a croton oil-induced
mouse ear edema model. Pretreatment of lipopolysaccharide-induced RAW 264.7 cells with Sargassum
muticum ethanol extract (0.1-100 μg/ml) inhibited lipopolysaccharide-induced production of nitric
oxide, interleukin-6 and tumour necrosis factor alpha in a dose-dependent manner. The expression of
lipopolysaccharide-induced, inducible nitric oxide synthase and cyclooxygenase-2 in the Sargassum
muticum ethanol extract-treated group was also suppressed in a dose-dependent manner. Furthermore, we
found that Sargassum muticum ethanol extract induced anti-inflammatory effects by inhibiting Mitogen-
activated protein kinases (extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38) and
nuclear factor kappa B, p65 phosphorylation in lipopolysaccharide-stimulated RAW 264.7 cells. The anti-
inflammatory activity of Sargassum muticum ethanol extract in vivo was evaluated in the ear edema model
of a croton oil-treated mouse. Compared to the untreated control, croton oil-induced ear edema was found
to be reduced by about 33 % upon treatment with 250 mg/kg Sargassum muticum ethanol extract.
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