Review on novel approach of oral drug administration : gastro retentive drug delivery system
By: Vaithilingam, V
.
Contributor(s): Dhamotharaswamy, Kumudha.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2023Edition: Vol.85(4), Jul-Aug.Description: 853-862p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Over several centuries, oral dosage forms have remained incomparably superior to alternative medication
delivery methods. For its ease of formulation and administration, its stability, and its excellent rate of patient
compliance, the oral route is preferred. Gastric emptying has been a major drawback for drugs that stay for
a very short period in the stomach. An innovative method of gastro-intestinal retention allows the dosage
form to stay in the gastrointestinal region for a longer period and maximize drug release. Gastro retentive
drug delivery system is applied for enhancing bioavailability, local action in the gastric region, maintaining
steady drug concentrations and minimising the dosage regimen. This review discusses the approaches used
in gastro retentive drug delivery system, which include floating, high density, muco-adhesive, magnetic and
various other systems. Floating systems are the most widely used approach under gastro retentive drug
delivery system. These are extensively used because of their simplicity. Drug content, hardness, particle size
analysis, weight variation and friability are some of the conventional tests for any dosage form. Along with
these, buoyancy studies, dissolution studies, and swelling index are also carried out. Techniques like magnetic
resonance imaging are widely used in in vivo evaluation. Yet, evaluating entire in vivo efficacy in the case of
small animals is a significant drawback. Gastro retentive drug delivery system is regarded as a formulative
strategy to improve the activity and bioavailability of the active pharmaceutical ingredient based on its
benefits and applications. It is anticipated that numerous more studies will uncover Gastro retentive drug
delivery system's full potential.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2024-0396 |
Over several centuries, oral dosage forms have remained incomparably superior to alternative medication
delivery methods. For its ease of formulation and administration, its stability, and its excellent rate of patient
compliance, the oral route is preferred. Gastric emptying has been a major drawback for drugs that stay for
a very short period in the stomach. An innovative method of gastro-intestinal retention allows the dosage
form to stay in the gastrointestinal region for a longer period and maximize drug release. Gastro retentive
drug delivery system is applied for enhancing bioavailability, local action in the gastric region, maintaining
steady drug concentrations and minimising the dosage regimen. This review discusses the approaches used
in gastro retentive drug delivery system, which include floating, high density, muco-adhesive, magnetic and
various other systems. Floating systems are the most widely used approach under gastro retentive drug
delivery system. These are extensively used because of their simplicity. Drug content, hardness, particle size
analysis, weight variation and friability are some of the conventional tests for any dosage form. Along with
these, buoyancy studies, dissolution studies, and swelling index are also carried out. Techniques like magnetic
resonance imaging are widely used in in vivo evaluation. Yet, evaluating entire in vivo efficacy in the case of
small animals is a significant drawback. Gastro retentive drug delivery system is regarded as a formulative
strategy to improve the activity and bioavailability of the active pharmaceutical ingredient based on its
benefits and applications. It is anticipated that numerous more studies will uncover Gastro retentive drug
delivery system's full potential.
Click on an image to view it in the image viewer
There are no comments for this item.