Enhancement of the Dissolution Rate of Indomethacin by Solid Dispersions in Low-substituted Hydroxypropyl Cellulose
By: Tascon-otero, Estefania
.
Contributor(s): Torre-Iglesias, Paloma
.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2019Edition: Vol. 81 (05).Description: 824-833p.Subject(s): PHARMACEUTICS![](/opac-tmpl/bootstrap/images/filefind.png)
Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
---|---|---|---|---|---|---|
![]() |
School of Pharmacy Archieval Section | Not for loan | 2020560 |
In the present study, new indomethacin formulations were developed in order to enhance the indomethacin dissolution rate by preparing solid dispersions using the freeze-drying method. The degree of alterations in the crystallinity of indomethacin was assessed according to the preparation method and by the addition of low-substituted hydroxypropyl cellulose. Solid dispersions improved the dissolution rate of indomethacin. Combined use of scanning electron microscopy, X-ray powder diffraction and differential scanning calorimetry revealed the basis of the increase in dissolution rate of indomethacin when formulated as low-substituted hydroxypropyl cellulose solid dispersions.
There are no comments for this item.