Identification and characterization of degradation products of valsartan by UPLC/Q-TOF-MS technique
By: Khan, Hamid.
Publisher: Raipur Asian Pharma Press 2021Edition: Vol.11(1), Jan-Mar.Description: 1-5p.Subject(s): PHARMACEUTICSOnline resources: Click here In: Asian journal of pharmaceutical researchSummary: UPLC/Q-TOF-MS (Ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric) technique has been applied for identification and characterization of degradation products of Valsartan. For identification of drugs, the Q-TOF mass spectrometer was operated in negative ionization mode and quantification was done using the MS/MS transitions at m/z 434.50 to 255.50. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7µm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.25 mL/min. Drug was degraded when treated with acid, alkali and oxidative stress conditions but found stable in photolytic condition. Degradation products were identified and possible degradation mechanisms were established.Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database | School of Pharmacy Archieval Section | Not for loan | 2022-0044 |
UPLC/Q-TOF-MS (Ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric) technique has been applied for identification and characterization of degradation products of Valsartan. For identification of drugs, the Q-TOF mass spectrometer was operated in negative ionization mode and quantification was done using the MS/MS transitions at m/z 434.50 to 255.50. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7µm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.25 mL/min. Drug was degraded when treated with acid, alkali and oxidative stress conditions but found stable in photolytic condition. Degradation products were identified and possible degradation mechanisms were established.
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