Zhang, Yi-Heng
Synthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection - Vol.56(2), Apr-June - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 573-579p.
It have been reported that the transition metal complex of Schiff base ligands have the
ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes
[Cd2
(L)2·(H 2
O)] (1), [Pb(L)·, [Pbe2
) were synthesized based on chelating hydrazone
ligand
N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested
by single crystal X-ray diffraction and determined by structure and tested for urease
resistance
in vitro. The complex 2 exhibited better the activities of inhibiting than the
positive control acetohydroxamic acid with an IC50 =2.5
μM, while the complex 1
showed weak activity, and complex 2 acted as an effective urease inhibitor.
PHARMACEUTICS
Synthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection - Vol.56(2), Apr-June - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 573-579p.
It have been reported that the transition metal complex of Schiff base ligands have the
ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes
[Cd2
(L)2·(H 2
O)] (1), [Pb(L)·, [Pbe2
) were synthesized based on chelating hydrazone
ligand
N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested
by single crystal X-ray diffraction and determined by structure and tested for urease
resistance
in vitro. The complex 2 exhibited better the activities of inhibiting than the
positive control acetohydroxamic acid with an IC50 =2.5
μM, while the complex 1
showed weak activity, and complex 2 acted as an effective urease inhibitor.
PHARMACEUTICS