Synthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection
By: Zhang, Yi-Heng
.
Contributor(s): Fang, Ze-Yu.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-June.Description: 573-579p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: It have been reported that the transition metal complex of Schiff base ligands have the
ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes
[Cd2
(L)2·(H 2
O)] (1), [Pb(L)·, [Pbe2
) were synthesized based on chelating hydrazone
ligand
N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested
by single crystal X-ray diffraction and determined by structure and tested for urease
resistance
in vitro. The complex 2 exhibited better the activities of inhibiting than the
positive control acetohydroxamic acid with an IC50 =2.5
μM, while the complex 1
showed weak activity, and complex 2 acted as an effective urease inhibitor.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1450 |
It have been reported that the transition metal complex of Schiff base ligands have the
ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes
[Cd2
(L)2·(H 2
O)] (1), [Pb(L)·, [Pbe2
) were synthesized based on chelating hydrazone
ligand
N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested
by single crystal X-ray diffraction and determined by structure and tested for urease
resistance
in vitro. The complex 2 exhibited better the activities of inhibiting than the
positive control acetohydroxamic acid with an IC50 =2.5
μM, while the complex 1
showed weak activity, and complex 2 acted as an effective urease inhibitor.
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